Unless you're running 100 foot lines to your speakers, it's really not worth it.
I was looking for more of a technical response, verses a should I, or shouldn't I one. As an example, a regular car tire, that we have all purchased time and time again. Compare that, with a high rolling resistances tire which is capable of producing higher over all MPG ( which it does as I've been using them for years ). I certainly make no claims as to knowing why this is, I only know I can substantiate their assertion. The negative is the tire costs a little more. The positive is one can expect to receive better gas mileage.
So what I'm looking for is, other than what I mentioned earlier, what is the different both for and against in using the 10 gauge over the 12 gauge wire.