My HT utilizes two M22s that use two mid-grade Velodyne 10" subs as stands. This combo sounds marvelous to me for movies and audio as well.

I would think that a couple of EP500s (being much higher end gear) with M22s, would be a killer combo.

I've always been a proponent of satellites and sub combos; however, since I've experienced my new M2s combined with my outstanding EP400 sub in my audio only system, I highly recommend going this route.