As I said, I've got the m60s and love them. My reasoning was partly a simple avoidance of "whatifitis" and partly a strong desire for floorstanding speakers. I'm sure I would be very happy with the sound of the m22s, but I plan on having these speakers for many years to come and want to avoid upgrading in a few years. Since this is my system for music and home theater, I figured it was better to go the m60 route for me. I don't know how those Bose sound, but the m60s are radically better than anything I had previously owned, they've honestly changed my music listening habits permanently.
