Axiom Home Page Forums General Discussion Advice from Axiom Owners VP160 V4 with M60 V2???

AFAIK there should be no problem. The difference between V2 and V4 should be subtle improvements, not "a different sound".

There might be slight efficiency differences from the different crossovers so you might need to tweek the center channel level by a dB or so, but that's just something to watch out for not a known issue. [EDIT - forget about v2 to v4 differences, you're going from VP100 to VP180 so you're probably going to have to tweak the level anyways]

I'm running a VP180 (which I think was introduced at v3) with M60ti's, which I think is more of a generation gap than you will have, and there's no noticeable timbral difference between them. I haven't done real A/B testing but the pink noise sounds very similar between M60 and VP180, which was not the case with the original VP100.