My opinion.
In your 3-channel room, you will hear a noticeable difference, especially with base response of the M60's lacking in the M22's.
In your dedicated HT, for movies, your EP350 and VP150 do most of the work so you shouldn't notice. For music, unless you switch to 2-channel direct mode, the difference should be minimal in all other formats as the base response should be handled by the EP350.
The caveat from Mojo will depend on the version of your speakers as there have been improvements over the years. If your M22's are much older than the M60's, I would place the newer speaker in the room you do most of your listening.
