I believe your only reason to go ADA1250-5 would be looking for the lowest possible noise floor.
Andrew stated in his recommendation thread: “As for which type of interconnects to use, we strongly suggest using balanced XLR connections if both your pre-amp/processor/receiver and your amplifier(s) have them available.“
In addition to that, craigsub had this to say in another thread: “We went with XLR's - there is noticeable "deeper blackness" to the overall presentation vs. RCA's - a clear indication of a lower noise floor.”
I don’t believe amplification would be an issue.
