Hi Mark
Are the subs equidistant to the main listening position? If so you might be fine.
I would recommend set to LFE and set all speakers to small with a crossover of 80hz to begin. If you are using small satellite speakers you may want to increase your crossover as required.
Im not a fan of LFE+Main. It may work in some rooms if the subwoofers arent placed or sized correctly. You are just artificially bolstering bass content by 6db or so below 120hz. With two subs set in opposing sides or front wall at 1/4 points you dont need to enable LFE+main.
You just need to calibrate your subs to mains correctly. Im not sure on your level of comfort with measuring tools, but to do this properly with multiple subs you cannot use an automated process. To add to this, if your subs are corner loaded the phase distortion caused by their placement makes it especially tough. Lots of output though…
Let us know if you want to go down the manual path. If auto is your speed then I would leave as LFE with 80hz and trust audyssey unless you hear boom or “slow bass”.
