The power rating of the speaker is almost entirely insignificant, and means nothing as far as the sound is concerned (unless you way over power or way under power them). See my comparison of M22s and M50s in another thread for 3 impressions of the two. Since the room is relatively large, I'd go with the VP150, QS8s and M50s or M60s. I realize that this could push the budget, so you may want to look into the outlet speakers (usually small blemish, no effect on the sound quality, same 5 year warranty) But do give Axiom a call! They know a lot and won't upsell you past your needs. In some cases, they even downsell!
