Hi animate,
Looking at your photo, there is no question that the wall surfaces and reflections in the alcove where the center and the TV are placed are changing the timbral (tonal) balance of the Vp150 and inhibiting clarity.
The alcoves with the M22ti's may be having similar effects, increasing the disparity in tonal balance between the center speaker and the mains. Do you have some sort of support you could use as a temporary stand to put the VP150 on below the TV screen (and in front) to remove the alcove influence from the center?
Once you've tried that, then you can see if the tonal match and intelligibility is better. You can decide on a different setup that would not place the three front speakers in the alcoves.
Try moving the M22ti's farther apart, perhaps putting them in the center of the left and right alcoves and toeing them in a bit towards the listening position.
There may be options with stands and/or wall-mounting that could largely eliminate the problems you're having.
Regards,
