EP500 will go deeper into the very low notes and will probably have flatter frequency response.

2xEP350 will move more air, should do a better job of handling large rooms, guessing will play a bit louder than 1xEP500, and having two subs can often give you smoother bass and lessen the effect of room modes by having sound originate in two parts of the room.

Disclaimer -- I bought my sub before I realized Axiom even made subs, so I haven't heard either 350 or 500.


M60ti, VP180, QS8, M2ti, EP500, PC-Plus 20-39
M5HP, M40ti, Sierra-1
LFR1100 active, ADA1500-4 and -8