it depends on your tastes. Do you like a laid back sound or a very accurate, transparent sound?

if you want transparent, get M22's with a sub.
Mellow sound? get M3's or M40's or M50's and a sub. M60's or M80's would likely not sound great in that size. I have tried my M80's in smaller rooms and they sound suffocated.

depends on your budget as well, but don't forget, stands for the M22's will likely run you another $100 CAD.