I have not found a single "best" setting for listening to music. As others have said, choosing the right mode for DVDs is pretty straightforward and the receiver will usually figure out what to do as long as it knows how many speakers you have.
Music is a different story because you are normally starting with stereo content and choosing from a bunch of different modes which use different techniques to simulate multiple channel audio. Sometimes Dolby Pro Logic II sounds best, sometimes Neo6, sometimes Logic 7 (a Harman Kardon proprietary mode) and sometimes I switch everything off and listen in stereo.
Just learn how to play with the buttons a bit and enjoy. As long as you know how to listen to DVDs in "Dolby Digital" 5.1 (or 6.1 if the disk is encoded that way) you aren't missing out on much.
M60ti, VP180, QS8, M2ti, EP500, PC-Plus 20-39
M5HP, M40ti, Sierra-1
LFR1100 active, ADA1500-4 and -8
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