Don't EQ the mids - not yet anyway. All you are doing by setting to small is rolling off the signal to the M22s. Don't just trust us, look at THX, Dolby, etc. They all suggest this. The PLUS setting could be an issue as Neon points out. What few sub-80hz notes the M22 is really generating may be cancelled out by the sub if the phase is off. That would give you a big hole in the range suck out the punch.
In my room, it turns out the plus setting is smoother, but I'm running tower speakers that can render good notes into the 50hz range. Go one step at a time. None of these are permanent, you can always go back to your original set up -
which you don't seem happy with! 
