Audyssey alters the response of the actual speaker itself and not that of the room despite being regarding as a room correction program.

Therefore Audyssey will make a difference. Whether you like it better with Audyssey equalization on or off will be different from user to user. There is not a absolute answer. Pick which one you prefer.

I’m armed and I’m drinking. You don’t want to listen to advice from me, amigo.

-Max Payne