We're on our second Odyssey. Bought a '99 (just off lease) in 2003, with around 60,000 miles. Drove it 7 years, and put a total of 187,000 miles on it. Replaced it with an '08 last year, with only 16,000 miles. Love them both. Couldn't imagine not having one with 3 kids. Inevitably, we will have one or two of the kids friends tagging along, or a set of parents.
Drive both the Honda and the Toyota. The Sienna will be quieter and smoother on the road, but the Odyssey will handle better. If you decide on the Honda, be sure it is an '05 or newer. That year they installed the transmission out of the Ridgeline. Lots of transmission problems prior to that.
As a side note, both ours are/were the base "stripper" versions. As much as I would love to have all the toys, we keep them forever, and there is way less to go wrong with base models.
(Sorry for the grammar, but it's midnight, and I'm tired)
