That room is HUGE!

I would go with the M60 VP150 QS8 option. Although I have not listened to the Ascends I do know the Axioms are great. If you really want that room to be off the hook go with a second sub along with a total of 4 QS8's. If you do that you will never leave the place but the extra pair of QS8's and sub may be a future thought but one that is recomended.