Get the M22ti and test drive it first, if you don't like what you hear...the most you would lose is the return shipping of a pair of bookshelf. IF you do like them...which I think you would, then it's safe to say you can either keep the M22ti for now, or return them and upgrade to M60, it share the same characteristics of M22ti but can handle more power, play louder, and lower. I think the M60 is ideal for most medium to large room.
If you don't think the M22ti is crisp or detail enough(unlikely) in the higher frequency region, then skip the M60 and go straight to M80, it sports TWO tweeters and more woofers. From what I've read the M80 is the beast and require more room to stretch its muscle, and more picky to position. Be prepare to power them with a decent amp capable of 4ohm. Give the M22ti a try, and I'm sure you'll be hooked!! The Axiom folks are a pleasure to deal with and the customer service they provide is second to none.
