A number of people run M2s and a leftover stereo amp/receiver on their PCs. At least one upgraded them to M22s, then built a home theater around them instead...

I would go with M3s myself and probably not bother with a sub...

M60ti, VP180, QS8, M2ti, EP500, PC-Plus 20-39
M5HP, M40ti, Sierra-1
LFR1100 active, ADA1500-4 and -8