Hey Tim,
I think you would be fine. Right now while I type on my 130" diag. screen I'm listening to some music on my m60's at a very low level, not to wake up my 1.5yr old right above me upstairs. We also watch tons of movies late at night. Keep in mind, the dialog (voices) during movies come from the center channel, so that will not change for you. The mains are there to help with the rest of the experience, like explosions.
My room is huge, and at lower volumes the m60's do very well. I would think they will do as good or better than your 22's.
good luck man.
