I ran my M22s as large LFE+ for quite sometime and enjoyed it. The M22 driver just does a natural roll off of any frequencies it can't handle, so no you won't hurt them. I would suggest running your system the way it sounds best to you. If you like the M22s set to large then run them that way.


Jason
M80 v2
VP160 v3
QS8 v2
PB13 Ultra
Denon 3808
Samsung 85" Q70