King, welcome. You'll certainly be able to enjoy great sound with your new Axioms, and you can feel free to start the enjoyment immediately; there's no significant "burn-in" with the Axioms(or other speakers)beyond the first minute or so of use(involving many thousands of cycles)which already occurred at the factory.
A placement of your two subs directly in diagonally opposite corners should work well for you. Since your subs will be separated by quite a distance there wouldn't be an advantage to running a daisy chain from the Axiom to the Paradigm, as there would be if they were located near each other. Use a Y connector similar to the one Michael(HomeDad)linked at the sub preout and run separate coaxial cables to the sub locations.
