As long as you have a good sub I think the M22s would work. I have them in an open main floor that is near the size (28x~20) of the room you are going to put them in and they work quite well on their own, no sub. The M80s of course just plain work no matter where they are, as long as you have the power behind them.

Have you looked at the hearing things forum for a possible audition in your area?

Jason
M80 v2
VP160 v3
QS8 v2
PB13 Ultra
Denon 3808
Samsung 85" Q70