Dave, when I auditioned at Axiom, I found the M22+sub to be remarkably similar to the M60 (ignoring the extra bottom end the sub delivers). The M22 + sub filled the 12x20x8 demo room nicely to 85db, a decent volume level. They would give you all the volume you could ever want in your room.
When we were at Mojo's comparing the v2s and the Ninja's I commented on how the v2 with the EP600 sounded somewhat like I remember the M60s sounding, so my impressions could be skewed by my M22v1s, as I swear they have more upper end/forwardness than the v2s, although Alan as stated the M22 is virtually unchanged. I can only find the XO layout to be different but looks to be the same parts. It could just be me