No, only a failure to amplify with flat frequency response from 20-20KHz and inaudibly low noise and distortion would affect the sound. This is the bottom line, there isn't anything else, and the design considerations to achieve it can vary as long as the results are there. These days the great thing for us is that it's routinely accomplished by receivers available for a few hundred dollars. Claims to a contrary(and plentiful helpings of BS by some manufacturers)abound of course, but they collapse when put to a properly controlled double-blind listening test.
