Coax with RCA would be my best guess, but I've never run one that far. As for the zones, I don't why it would not work other than the issues with distrib of digital media, if that is still an issue (was on older Denons). But you can test that before you run the wire.

Panny 3000 PJ, 118" Carada, Denon 3300, PS3, Axiom QS8, PSB 5T, B&W sub, levitating speaker wire