I suspect the difference between these two configurations would be a little fuller sound in the high and mid and lower mid range spectrum with the M60 perhaps with some redundancy that may prove to be richer(that's not a necessarily bad thing) whereas with M22's there would be no overlap and most likely a cleaner and possibly brighter forward sounding mid range and highs with very clean bass. I'm a classical listener and am unsure which would give be the most satisfaction....I'm thinkin M60's with an EP 350. Any opinions?
