Armen, the M22s w sub is very similar, sonically, to the M80s w sub, according to many here on the forums who have heard both and would be a good choice for this size of room. Your room is about 1200 cu ft assuming an 8 ft ceiling, if you used floor standers like the M60s or 80s, they would be fine at modest listening levels but really need more space if played at higher levels. You might also want to have a look at Axiom's 'W' series speakers, these are in-wall versions of some of Axioms other speakers...this would help keep the room uncluttered and give it a clean look as opposed to having some large cabinets/stands ect., cutting the room size down farther.
