I own both and, other than the M60s having a bit more bottom end and the ability to play louder, there is not a significant difference in the sound quality. With a sub, you really won't be missing much.

Having said that, the reason that I own both is because I bought the M22s, and immediately started wondering how much better the M60s were. Now that I have the 60s, I'm pining for the 80s. It's a disease for which money is the cure.

I started out with nothing & I've still got most of it left
M60 VP160 QS8 EP350
M22 VP100
Algonquins