It's all really dependent on room size, and how far away you'll be sitting. From what you've said, I think the M22's would be the best option. The M2's are a bit small for that room and sitting 10' back. On the other hand, you may not enjoy all the benefits of jumping to the M60's in that room either. It's a little on the small side for them as well. They'd probably work alright, but you mention budget is an issue, and the M60's are a considerable jump up from the M22's in price. (totally worth the price if you've got the right room though!)
If you ask me, I'd go with the M22's with a VP150 center, and a Hsu STF-2 subwoofer. QS4 (or QS8) surrounds.
Please let us know what you finally end up with - even if it's not Axioms, we'd love to hear your thoughts.
Enjoy your shopping. It's half the fun of this hobby!
