I have run my single VP100 vertically using a mono signal and it sounded really good, not quite as warm as an M22 due to the lack of a port. Running a full LCR with the VP100 inside a bookshelf/entertainment center should work very well as this set up would have no rear porting to worry about.

Jason
M80 v2
VP160 v3
QS8 v2
PB13 Ultra
Denon 3808
Samsung 85" Q70