Yes you can do this, I actually have a horizontal EP600, that I often place in a vertical orientation. Keep in mind that the position under your table might NOT be the ideal position in your room for best results.

M80s VP180 4xM22ow 4xM3ic EP600 2xEP350
AnthemAVM60 Outlaw7700 EmoA500 Epson5040UB FluanceRT85