You might be able to cross the M50's a bit lower than 80hz while the M22 would be best crossed higher at 80hz but since you are going to be using a capable subwoofer like the EP500 that little bit of extension you would gain with the M50 is not really that important. The EP500 fills that void.

I’m armed and I’m drinking. You don’t want to listen to advice from me, amigo.

-Max Payne