Flyer, ideally tweeters should be at ear level. Since the bottom of your screen will be at eye(or ear)level, the M22s should be positioned upside-down so that the tweeters will be just a bit above that. The M2 on-wall is very unobtrusive and should pose no aesthetic problem positioned vertically at the bottom of the screen so that its tweeter is just a little lower than those of the M22s.

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Enjoy the music, not the equipment.