The M22s could work in a 7.1 as rear channels if they have enough room behind the listening area to disperse into the room(a fairly large room) but in a 5.1 room I'd be using the Q's. If you are going to set up an HT down the road, you could use the M22's as mains with a decent sub(300wts+) and Q's as surrounds...that would make for an excellent system and wouldn't leave you wanting except for a very large room upwards +3000cu ft. where M60s/80s would be more desirable(depending on your listening level).
The q's are designed for surround duties and would be very compromised in a 2.1 system.
