The 2 are very similar but I prefer the cleaner more forward midrange the M80s present, which IMO is more noticeable at lower volume levels, the M60s IMO seemd perhaps more neutral or slightly recessed at lower volumes. These differences pretty much disapear at higher listening levels. The M80s also have better bass, but much of this is being pretty picky, they are both excellent speakers. If I wasn't used to my M22Ti's I am pretty sure I would still have M60's as I prefer its look to the full grill of the M80, also keep in mind all of my comparisons are with v2 speakers not the new v3 designs, so YMMV.
