I think they both look interesting. Very compact.
Something i would have loved in my university days. A pair of M22s with a small sub and those int amps?
Instead i had housemates who bought speakers out of the back of white trucks. I'll give them this; they were loud.
Sub suggestions sure; if you want more bass. You can always test out the M22s first by themselves and if you want to 'feel' a bit more sound, make the low end have more oomph, pickup a sub.
How large?
Depends on your uses.
Based on the amp choices, you seem to be aiming for compact so in that sense, i wouldn't get anything larger than the EP350 (of Axiom selections that is as there are lots of other brands out there).