The M5HP cabinet is a bit larger volume. The height is very similar. The M22 doesn't go as low. I heard the M22ti and it sounded thin but many others like it. Compared to the M3, the M22 and M5 sound more like real music. The M3v4 is very mellow and soothing but not as detailed (accurate).

House of the Rising Sone
Out in the mid or far field
Dedicated mid-woofers are over-rated