Razor, I haven't heard the 22s but a friend who demo-ed my M60s said the 22s sound quite a bit "leaner". I would bet that you could get great sound w/ M22s and a sub, but it may require more tinkering than M60s + a sub. With your special requirements I would suggest spending the little extra dough (if you got it) for the ease of set-up (and likely better sounding result). My $.02.