I originally purchased the m22s, but, I had an itch which I needed to scratch. I always wondered if the m50s would have been a better choice. So, I ordered the m50s and listened to them side by side with the 22s for about 3 weeks. Initially, the differences were minor, but after a few days, the soundstage and clarity of the m22s overwhelmed the 50s. Luckily, Amie allowed me to return them. I had trouble believing that there could be much difference between the laid back sound of the m3, m40, m50s vs the clarity of the m2, m22, m60, m80 line up, but there is. Both the m22s and the m50s are nice speakers, but the laid back quality of the m50s wasn't what I was looking for.