Considering that you will be doing 70% movies and 30% music, and that you plan on a buying a sub, my response to "Will the M22s have clarity and be clear at a moderate listening level?" -- is not just yes, but hell yes!

I have owned the m22s, and now own the m60. For watching movies at moderate levels, I really could not tell much of a difference at all (my room is bigger than yours).

M60s (previously 22ti)
VP150
Epik Castle
Q8 Surrounds