I have a 30 x 30 room with m60's vp150 ep350 and 4-qs8's and it works fine. I would be a little concerned about using the smaller speakers. Are you really planning on using the entire space for movies? Also, the sub would be ok, but you might find it a bit small for that room. I'm actually considering getting another ep350 for my space.

M80s VP180 4xM22ow 4xM3ic EP600 2xEP350
AnthemAVM60 Outlaw7700 EmoA500 Epson5040UB FluanceRT85