If you just want a good burger, Clown Alley is the place to go. It's on the corner of Columbus and Jackson, just about in North Beach. Very close to the Transamerica.
I recommend doing Alcatraz (buy the tickets well, well in advance!) It's a great tour, and not nearly so tourist as one might believe.
As for the vette and the hills--you'll have to do it at 3 AM. Otherwise, there is traffic. Lots and lots of traffic.
If you're willing to dare crossing the Oakland Bay Bridge, my favorite restaurant is Jojo. It's a French restaraunt owned/run by some former chefs for Chez Panisse (think French Laundry, only slightly easier to get reservations and not quite as expensive). Jojo's in Piedmont, open Tuesday-Saturday for dinner only.
