th3at3rguy,
Every room is different, we can't tell you what adjustment's to make with your sub/m22's/and your room. We can give you pointers. There is no way you want the volume (gain) on the back of the sub cranked all the way. Most of us have our EP500's and EP600's set very low, around 6-7 o'clock on the knob.
You want to run the built in test tones on the receiver and use an SPL meter, to calibrate everything to about 75dB's. You do this by adjusting the speakers and sub levels on the receivers setup menu up/down until they are at the same dB levels. Many receivers have a built in test tone and microphone that you place in the primary seat, this will also adjust the distance and levels without needing an SPL meter.
