If your wife is like mine (mind you we have only been married a year on Nov 12) she will like things that take your personal time to get.
I gave her a hand painted ceramic oversized mug that took me 3 lunch hours from work to complete at the store for our 1 year...to say that she loved it is an understatement, and I reaped what I sowed
It has a personal touch that women love.
I am not a sissy boy by any means! What I actually suggest is you take your kids with you to the ceramic place (if you can find a time when she is busy and won't know) and get them to make her something too. I am sure a Mom of 2 would love hand made products from her kids and her husband.
In addition to that, you can never go wrong with slippers! (if you live in calgary...-41 with windchill yesterday)