Hi BigRed,
I'm an owner of both M22ti's and M3ti's. I would say that if you are going to use the speakers on a desk for near-field listening the M3Ti's are great speakers, with or without a sub. And they would be fine for general listening as well. But you might want to consider the M22ti's because they would "scale up" to a larger room or into a home theater type of system very well.
Personally, I use M3Ti's in my office without a subwoofer and just enjoy the heck out of them. For my HT, I use the M22's for the fronts and they work very well with the EP350 sub to create a pretty slammin' setup. I wouldn't recommend the 22's as mains in a much larger room than mine though (12 x 16 x 9).
