I went with the M50's (backed-up by the EP-500 sub) and love it. With my budget tight, it won over the M22's in my case because with 3 kids <=5yrs old, I was afraid of having "top-heavy" stand mounted speakers. Plus, I didn't really have a set-up for placing speakers on bookshelves.
Maybe someday I'll join the M80 club, but for now I'm very pleased with the output and the warmth of my system in my ~1300ft3 room.

Epic 50 - 500 System ( M50 / QS4 / VP100 / EP500 )