I assume your saying W22's, not M22's installed in a wall, which would be a mistake with the rear port. The W22's are designed to have the same sonic ability as the m22's, which are highly regarded. Unless your room is HUGE and your listening to insane volumes, the W22's should do just fine.

Will they give you the same performance as a floorstanding tower, no, but if you have a sub and everything calibrated correctly, it should be fine.

M80s VP180 4xM22ow 4xM3ic EP600 2xEP350
AnthemAVM60 Outlaw7700 EmoA500 Epson5040UB FluanceRT85