I have my 80's set to large and the 150 set to small. I realize that many recommend setting your mains to small as well, but I wouldn't dream of restricting the M80's from doing what they do best, play EVERYTHING!!! IMO they play the midbass much better than a sub can. And when I say midbass I'm talking 35 - 80 hz. That's why I refuse to set my mains to small, therefore restricting everything below 80 hz on them.

My Stuff :

M80's
QS8's
VP150
EP800
Denon 4802
Emotiva XPA-3
Samsung BD-P3600
Sharp 65 Inch Aquos LCD