I've got the Harmony One and do like it...especially for turning everything on initially, and for powering everything off. In my case, I haven't gotten rid of all of other remotes. I have a Tivo Series 3, and I must admit it has an exceptionally well designed remote. If it's close by, I still find myself (even after a year or so) grabbing the Tivo remote to do common functions because, well, it's a tad quicker in response. Setting the One to minimum possible delay still isn't as quick as the original remote. It may not bother some, but I notice it.
It's excellent for switching sources when going from TV watching to gaming to music listening, etc., but I still find myself sometimes grabbing the original remotes for certain functions as it just seems easier than going thru several screens on the One. I have no WAF to deal with, so several remotes on the couch is no issue!
