Hey, not sure what you mean by "maybe he's running mains in full range" but my settings in Speaker config are as follows
Front-Large
Center-Large
Sub-yes
Surround A-Large
Surround B-No
Sub-woofer Mode-LFE+Main
Crossover set to 80Hz
I wouldn't be running your VP-150 and your QS8s as "large", you're wasting lots of power sending bass signals to them that they can't produce. And personally, I can't imagine you needing to run your M60s as Large or in LFE+Main modes either, when you have an EP500 sub.
You're not only wasting power, you're losing bass from the center and surround channels because the bass signals that can't be reproduced by those speakers are disappearing rather than being reproduced by your very, very capable sub.
In other words, I think you'll be fine if you set your receiver as recommended.
